Chronic Myeloid Leukemia (CML)

Chronic myelogenous or chronic granulocytic leukemia is a type of myoproliferative disease characterized by the presence of characteristic chromosome known as the Philadelphia chromosome.Chronic myeloid leukemia (CML) arises due to the chromosomal aberration in which reciprocal translocation of the Abelson gene on chromosome 9 to break-point cluster region gene on chromosome 22 results in the creation of fusion oncogene, bcr-abl (9; 22) (q34; q11). CML is now treated with Tyrosine Kinase Inhibitors (TKI’s).